Our vision is to enable the optimisation of personalised medicine through the use of noninvasive imaging techniques.
The use of imaging, allowing us to "see" inside the body without invasive surgery, essentially removes the "black box", so researchers can see if the therapy is working as it should. In the figure above, the use of an imaging agent to make the cell therapy visible means that the cells can be followed in a patient. This allows the optimisation of the therapy, even for each individual. Imaging can be similarly applied to other forms of therapy as well.
what we do
We are working on developing noninvasive in vivo imaging techniques to comprehensively monitor modern personalised medicine, such as cell therapies, targeted therapies and theranostics. We are working with multimodal in vivo imaging (1H and 19F MRI, PET, CT, SPECT, bioluminescence, ultrasound, optoacoustics and fluorescence).
We are involved in all aspects of this work, including label development and formulation for human (GMP) and preclinical use, cell handling and labeling, in vivo animal models, imaging, development for clinical application, upscaling production and image analysis. The work is inherently multidisciplinary, and we work with immunologists, chemists, physicists and physicians.
My group works at both the preclinical and clinical level, including GMP production of contrast agents for human use. I am also actively involved in commercialisation of this work, through several patents, dealing with regulatory agencies and am in the process of setting up a spin-off.
IN SIMPLE WORDS
We are working hard to improve treatments like cell therapy by making the treatment visible using imaging, such as ultrasound imaging. Being able to see where the cells are and if they are alive can help to tailor the therapy to the patient, and also to optimise therapy for each patient individually.
KEYWORDS: Mangala Srinivas, Nijmegen, Radboud, 19F MRI, cell tracking, multimodal, imaging, nanoparticles, PET, SPECT, cell therapy, dendritic, T cells, macrophage, plaque, cardiovascular, in vivo imaging, photoacoustic, optoacoustic, ultrasound, fluorescence