Mangala Srinivas, Nijmegen, Radboud, 19F MRI, cell tracking, multimodal imaging, nanoparticles, PET, SPECT, cell therapy, dendritic, T, macrophage, plaque, cardiovascular, research, in vivo, photoacoustic, optoacoustic, ultrasound, fluorescence, tumour, clinical, GMP, YAE

OLGA KOSHKINA, PH.D.


Research interests

Multifunctional nanoparticles including stimuli-responsive materials, multiphase, perfluorocarbon-loaded particles and hybrid colloids for nanomedicine

Design of nanomaterials for in vivo imaging of the therapeutic immune cells

Interactions of nanoparticles with biomolecules and cells

Development of analytical methods to characterize complex colloidal systems


current projects

Perfluorocarbon-loaded nanoparticles for long-term ultrasound imaging

Nanoparticles with solid perfluorocarbon as sensors for 19F MRI

Design of nanoparticles with perfluorocarbons and gadolinium chelates for contrast enhanced 19F MR imaging


brief CV

Since May 2014: postdoc at Multiscale Imaging Lab, part of Tumor Immunology Lab (TIL), Radboud Institute for Molecular Life Science

 

Feb. 2014: PhD in polymer and colloid chemistry from Technical University of Berlin in collaboration with Federal Institute for Materials Research and Testing, Berlin and Fraunhofer ICT-IMM Mainz

Thesis Topic: Multifunctional Poly(organosiloxane) Nanoparticles as a Model System for Biomedical Applications

 

April 2010: MSc in biomedical chemistry form Johannes Gutenberg-University of Mainz

 

April 2005-April 2010: Studies in biomedical chemistry, Johannes Gutenberg-University, Mainz, Germany


key publications

1       Perfluorocarbon/Gold-Loaded Cement for Non-Invasive In Vivo Assessment of Bone Fillers Using 19F Magnetic Resonance Imaging and Computed Tomography

Mastrogiacomo, S.‡; Dou, W.‡; Koshkina, O.; Srinivas, M.; Boerman, O.C.;. Jansen, J. A.; Heerschap, A.; Walboomers, X. F.*

ACS Appl. Mater. Interfaces 2017, 9, 22149-22159

 

2       Tuning the Surface of Nanoparticles: Impact of Poly(2-ethyl-2-oxazoline) on Protein Adsorption in Serum and Cellular Uptake

Koshkina O. ‡,*; Westmeier, D.‡;  Lang T.; Bantz, C.; Hahlbrock, A.; Würth, C.; Resch-Genger, U.; Braun, U.; Thiermann, R.; Weise, C.; Eravci, M.; Mohr B.; Schlaad, H.; Stauber, R. H.; Docter, D.*; Bertin A.; Maskos M.*

Macromol. Biosci. 2016, 16, 1287−1300.

 

3       Temperature-Triggered Protein Adsorption on Polymer-Coated Nanoparticles in Serum

Koshkina O.; Lang T.; Docter D.; Schlaad, H.; Lang, T.; Docter, D.; Stauber, R.; Secker S.; Schlaad H.; Weidner, S. Mohr B.; Maskos M. ‡; Bertin A. ‡

Langmuir, 2015, 31, 8873–8881

 

4       The surface properties of nanoparticles determine the agglomeration state and the size of the particles under physiological conditions

Bantz C.‡; Koshkina O. ‡; Lang T. ‡; Galla H-J.; Kirkpatrick C- J.; Stauber R.; Maskos M.

Beilstein J. Nanotechnol., 2014, 5, 1774–1786.